| Children |
| | 1. Anne Griffith, b. 1499 d. 1545, Anglesey, Wales, United Kingdom (Age 46 years) |
| | 2. Margred Griffith, b. 1500, Port Penrhyn, Caernarfonshire, Wales, United Kingdom d. 1594, Fulham, London, England, United Kingdom (Age 94 years) |
| | 3. Catherine Griffith, b. 1503, Penrhyn Castle, Caernarfonshire, Wales, United Kingdom d. 11 Mar 1540, Anglesey, Wales, United Kingdom (Age 37 years) |
| | 4. Grace Griffith, b. 1503, Port Penrhyn, Caernarfonshire, Wales d. 1541, Wales (Age 38 years) |
| | 5. Thomas Griffith, b. Abt 1505, Caernarfonshire, Wales d. Wales, United Kingdom  |
| | 6. Huw Griffith, b. Abt 1507, Port Penrhyn, Caernarfonshire, Wales, United Kingdom d. DECEASED |
| | 7. Ellen Griffith, b. 1508, Penrhyn by Conway, Caernarfonshire, Wales, United Kingdom d. 1529, Wales, United Kingdom (Age 21 years) |
| | 8. Elizabeth Griffith, b. 1508, Penrhyn Castle, Caernarfonshire, Wales, United Kingdom d. 1540, Milton, Hampshire, England, United Kingdom (Age 32 years) |
| | 9. Dorothy Griffith, b. 1508, Penrhyn Castle, Caernarfonshire, Wales d. Gwydir, Caernarfonshire, Wales, United Kingdom  |
| | 10. Isabel Griffith, b. Abt 1510, Penrhyn Castle, Caernarfonshire, Wales, United Kingdom d. Abt 1580, Llandegai, Caernarfonshire, Wales, United Kingdom (Age 70 years) |
| | 11. Sibyl Griffith, b. 1510, Penrhyn Castle, Caernarfonshire, Wales, United Kingdom d. 16 Feb 1613, Bodowen, Anglesey, Wales (Age 103 years) |
| | 12. William Griffith, b. 7 Nov 1510, Caernarfonshire, Wales, United Kingdom d. 28 Nov 1587, Caernarfonshire, Wales, United Kingdom (Age 77 years) |
| | 13. Esquire Sir Edward Griffith, b. 18 May 1511, Anglesey, Wales d. 11 Mar 1540, Diocese of Dublin, Leinster, Ireland (Age 28 years) |
| | 14. Hugh Griffith, b. 1511, Llandegai, Caernarfonshire, Wales, United Kingdom d. 1562, Wilmington, New Hanover, North Carolina, United States (Age 51 years) |
| | 15. Rhys Griffith, b. Abt 1511, Penrhyn Castle, Caernarfonshire, Wales, United Kingdom d. 30 Jul 1580, Diocese of Dublin, Leinster, Ireland (Age 69 years) |
| | 16. Jane Griffith, b. 1514, Penrhyn Castle, Caernarfonshire, Wales, United Kingdom d. 1572, Mostyn, Flintshire, Wales, United Kingdom (Age 58 years) |
| | 17. Ellen Griffith, b. 1515, Penrhyn by Conway, Caernarfonshire, Wales, United Kingdom d. DECEASED |
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